Interplay of Na(+) Balance and Immunobiology of Dendritic Cells

Local Na(+) balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na(+) levels. On the other hand, Na(+) availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of...

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Autores principales: Neubert, Patrick, Schröder, Agnes, Müller, Dominik N., Jantsch, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449459/
https://www.ncbi.nlm.nih.gov/pubmed/30984179
http://dx.doi.org/10.3389/fimmu.2019.00599
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author Neubert, Patrick
Schröder, Agnes
Müller, Dominik N.
Jantsch, Jonathan
author_facet Neubert, Patrick
Schröder, Agnes
Müller, Dominik N.
Jantsch, Jonathan
author_sort Neubert, Patrick
collection PubMed
description Local Na(+) balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na(+) levels. On the other hand, Na(+) availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair is rather limited. Current evidence suggests that the impact of increased Na(+) on DCs is context dependent. Moreover, it is conceivable that DC immunobiology might also be influenced by Na(+)-rich-diet-induced changes of the gut microbiome.
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spelling pubmed-64494592019-04-12 Interplay of Na(+) Balance and Immunobiology of Dendritic Cells Neubert, Patrick Schröder, Agnes Müller, Dominik N. Jantsch, Jonathan Front Immunol Immunology Local Na(+) balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na(+) levels. On the other hand, Na(+) availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair is rather limited. Current evidence suggests that the impact of increased Na(+) on DCs is context dependent. Moreover, it is conceivable that DC immunobiology might also be influenced by Na(+)-rich-diet-induced changes of the gut microbiome. Frontiers Media S.A. 2019-03-29 /pmc/articles/PMC6449459/ /pubmed/30984179 http://dx.doi.org/10.3389/fimmu.2019.00599 Text en Copyright © 2019 Neubert, Schröder, Müller and Jantsch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Neubert, Patrick
Schröder, Agnes
Müller, Dominik N.
Jantsch, Jonathan
Interplay of Na(+) Balance and Immunobiology of Dendritic Cells
title Interplay of Na(+) Balance and Immunobiology of Dendritic Cells
title_full Interplay of Na(+) Balance and Immunobiology of Dendritic Cells
title_fullStr Interplay of Na(+) Balance and Immunobiology of Dendritic Cells
title_full_unstemmed Interplay of Na(+) Balance and Immunobiology of Dendritic Cells
title_short Interplay of Na(+) Balance and Immunobiology of Dendritic Cells
title_sort interplay of na(+) balance and immunobiology of dendritic cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449459/
https://www.ncbi.nlm.nih.gov/pubmed/30984179
http://dx.doi.org/10.3389/fimmu.2019.00599
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