HIV Controllers Exhibit Effective CD8(+) T Cell Recognition of HIV-1-Infected Non-activated CD4(+) T Cells

Even with sustained antiretroviral therapy, resting CD4(+) T cells remain a persistent reservoir of HIV infection, representing a critical barrier to curing HIV. Here, we demonstrate that CD8(+) T cells recognize infected, non-activated CD4(+) T cells in the absence of de novo protein production, as...

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Detalles Bibliográficos
Autores principales: Monel, Blandine, McKeon, Annmarie, Lamothe-Molina, Pedro, Jani, Priya, Boucau, Julie, Pacheco, Yovana, Jones, R. Brad, Le Gall, Sylvie, Walker, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449512/
https://www.ncbi.nlm.nih.gov/pubmed/30943397
http://dx.doi.org/10.1016/j.celrep.2019.03.016

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