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In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection model

OBJECTIVES: To characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of lefamulin in the neutropenic murine thigh infection model to ascertain (i) which PK/PD index best correlates with efficacy and (ii) whether the magnitude of the index that drives efficacy varies for different pathogen...

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Detalles Bibliográficos
Autores principales:	Wicha, Wolfgang W, Craig, William A, Andes, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Supplement Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449574/ https://www.ncbi.nlm.nih.gov/pubmed/30949706 http://dx.doi.org/10.1093/jac/dkz085

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