BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection

B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense re...

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Autores principales: Yu, Xueping, Zheng, Yijuan, Mao, Richeng, Su, Zhijun, Zhang, Jiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449624/
https://www.ncbi.nlm.nih.gov/pubmed/30984188
http://dx.doi.org/10.3389/fimmu.2019.00617
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author Yu, Xueping
Zheng, Yijuan
Mao, Richeng
Su, Zhijun
Zhang, Jiming
author_facet Yu, Xueping
Zheng, Yijuan
Mao, Richeng
Su, Zhijun
Zhang, Jiming
author_sort Yu, Xueping
collection PubMed
description B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV infection.
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spelling pubmed-64496242019-04-12 BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection Yu, Xueping Zheng, Yijuan Mao, Richeng Su, Zhijun Zhang, Jiming Front Immunol Immunology B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV infection. Frontiers Media S.A. 2019-03-29 /pmc/articles/PMC6449624/ /pubmed/30984188 http://dx.doi.org/10.3389/fimmu.2019.00617 Text en Copyright © 2019 Yu, Zheng, Mao, Su and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yu, Xueping
Zheng, Yijuan
Mao, Richeng
Su, Zhijun
Zhang, Jiming
BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
title BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
title_full BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
title_fullStr BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
title_full_unstemmed BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
title_short BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
title_sort btla/hvem signaling: milestones in research and role in chronic hepatitis b virus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449624/
https://www.ncbi.nlm.nih.gov/pubmed/30984188
http://dx.doi.org/10.3389/fimmu.2019.00617
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