PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration

Our previous studies showed that in a mouse model in which PI3K-AKT activation was increased (YF mice), osteoclast numbers and levels of SDF-1, a chemokine, were augmented. The purpose of this study was to delineate the role of PI3K activation in regulating SDF-1 production and examine whether SDF-1...

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Detalles Bibliográficos
Autores principales: Adapala, Naga Suresh, Root, Sierra, Lorenzo, Joseph, Aguila, Hector, Sanjay, Archana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449702/
https://www.ncbi.nlm.nih.gov/pubmed/30989092
http://dx.doi.org/10.1016/j.bonr.2019.100203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449702/
https://www.ncbi.nlm.nih.gov/pubmed/30989092
http://dx.doi.org/10.1016/j.bonr.2019.100203

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