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Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study

BACKGROUND: Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the relationship between MPV/PC and colorectal cancer is unclear. This retrospecti...

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Autores principales: Wu, Yang-Yang, Zhang, Xuan, Qin, Yuan-Yuan, Qin, Jin-Qiu, Lin, Fa-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449942/
https://www.ncbi.nlm.nih.gov/pubmed/30947696
http://dx.doi.org/10.1186/s12885-019-5504-9
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author Wu, Yang-Yang
Zhang, Xuan
Qin, Yuan-Yuan
Qin, Jin-Qiu
Lin, Fa-Quan
author_facet Wu, Yang-Yang
Zhang, Xuan
Qin, Yuan-Yuan
Qin, Jin-Qiu
Lin, Fa-Quan
author_sort Wu, Yang-Yang
collection PubMed
description BACKGROUND: Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the relationship between MPV/PC and colorectal cancer is unclear. This retrospective clinical study aimed to evaluate the diagnostic value of MPV/PC in colorectal cancer. METHODS: Hematological examinations were performed at initial diagnosis in patients with colorectal cancer (n = 186) or adenomatous polyp (n = 132) and healthy controls (n = 108). Hematological parameters evaluated included white blood cells, red blood cells, hemoglobin, neutrophils, lymphocytes, monocytes, PC, and MPV. Statistical analyses included Student’s t-test, one-way ANOVA or Kruskal-Wallis H test, chi-square tests, Spearman’s correlation test and receiver operating characteristic (ROC). ROC curve was used to evaluate the diagnostic values of MPV and MPV/PC in colorectal cancer. RESULTS: Among these groups, MPV was significantly lower in colorectal cancer than in adenomatous polyp (p = 0.002) and healthy controls (p < 0.001) but did not significantly differ between adenomatous polyp and healthy controls (p = 0.210). MPV/PC was lower in colorectal cancer compared with adenomatous polyp and healthy controls (p < 0.001) and in adenomatous polyp compared with healthy controls (p = 0.010). MPV did not significantly differ among colorectal cancer subgroups, while MPV/PC significantly differed between TNM stages and the presence/absence of lymph node metastasis. MPV/PC was negatively correlated with the neutrophil to lymphocyte ratio(NLR) (p = 0.002) and platelet to lymphocyte ratio(PLR) concentration (p < 0.001). In the differential diagnosis between colorectal cancer and adenomatous polyp, MPV/PC produced a larger ROC curve than MPV, NLR or PLR alone. Using MPV/PC to distinguish between colorectal cancer and controls produced a larger AUC than using MPV or NLR alone. CONCLUSIONS: MPV/PC may be useful for the diagnosis of colorectal cancer. However, further studies are warranted to include additional regions and more data, to assess the utility of MPV/PC as a novel diagnostic screening tool for colorectal cancer.
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spelling pubmed-64499422019-04-15 Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study Wu, Yang-Yang Zhang, Xuan Qin, Yuan-Yuan Qin, Jin-Qiu Lin, Fa-Quan BMC Cancer Research Article BACKGROUND: Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the relationship between MPV/PC and colorectal cancer is unclear. This retrospective clinical study aimed to evaluate the diagnostic value of MPV/PC in colorectal cancer. METHODS: Hematological examinations were performed at initial diagnosis in patients with colorectal cancer (n = 186) or adenomatous polyp (n = 132) and healthy controls (n = 108). Hematological parameters evaluated included white blood cells, red blood cells, hemoglobin, neutrophils, lymphocytes, monocytes, PC, and MPV. Statistical analyses included Student’s t-test, one-way ANOVA or Kruskal-Wallis H test, chi-square tests, Spearman’s correlation test and receiver operating characteristic (ROC). ROC curve was used to evaluate the diagnostic values of MPV and MPV/PC in colorectal cancer. RESULTS: Among these groups, MPV was significantly lower in colorectal cancer than in adenomatous polyp (p = 0.002) and healthy controls (p < 0.001) but did not significantly differ between adenomatous polyp and healthy controls (p = 0.210). MPV/PC was lower in colorectal cancer compared with adenomatous polyp and healthy controls (p < 0.001) and in adenomatous polyp compared with healthy controls (p = 0.010). MPV did not significantly differ among colorectal cancer subgroups, while MPV/PC significantly differed between TNM stages and the presence/absence of lymph node metastasis. MPV/PC was negatively correlated with the neutrophil to lymphocyte ratio(NLR) (p = 0.002) and platelet to lymphocyte ratio(PLR) concentration (p < 0.001). In the differential diagnosis between colorectal cancer and adenomatous polyp, MPV/PC produced a larger ROC curve than MPV, NLR or PLR alone. Using MPV/PC to distinguish between colorectal cancer and controls produced a larger AUC than using MPV or NLR alone. CONCLUSIONS: MPV/PC may be useful for the diagnosis of colorectal cancer. However, further studies are warranted to include additional regions and more data, to assess the utility of MPV/PC as a novel diagnostic screening tool for colorectal cancer. BioMed Central 2019-04-04 /pmc/articles/PMC6449942/ /pubmed/30947696 http://dx.doi.org/10.1186/s12885-019-5504-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wu, Yang-Yang
Zhang, Xuan
Qin, Yuan-Yuan
Qin, Jin-Qiu
Lin, Fa-Quan
Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
title Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
title_full Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
title_fullStr Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
title_full_unstemmed Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
title_short Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
title_sort mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449942/
https://www.ncbi.nlm.nih.gov/pubmed/30947696
http://dx.doi.org/10.1186/s12885-019-5504-9
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