Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families

BACKGROUND: In the majority of familial breast cancer (BC) families, the etiology of the disease remains unresolved. To identify missing BC heritability resulting from relatively rare variants (minor allele frequency ≤ 1%), we have performed whole exome sequencing followed by variant analysis in a v...

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Detalles Bibliográficos
Autores principales: Shahi, Rajendra Bahadur, De Brakeleer, Sylvia, Caljon, Ben, Pauwels, Ingrid, Bonduelle, Maryse, Joris, Sofie, Fontaine, Christel, Vanhoeij, Marian, Van Dooren, Sonia, Teugels, Erik, De Grève, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449945/
https://www.ncbi.nlm.nih.gov/pubmed/30947698
http://dx.doi.org/10.1186/s12885-019-5494-7

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