Cargando…

Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

BACKGROUND: Internal tandem duplications (ITD) within the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3) represent a poor prognostic indicator in acute myeloid leukemia (AML). Therapeutic benefits of tyrosine kinase inhibitors, such as sorafenib, are limited due to the emergence of drug r...

Descripción completa

Detalles Bibliográficos
Autores principales:	You, Xin, Jiang, Weiye, Lu, Wenhua, Zhang, Hui, Yu, Tiantian, Tian, Jingyu, Wen, Shijun, Garcia-Manero, Guillermo, Huang, Peng, Hu, Yumin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449955/ https://www.ncbi.nlm.nih.gov/pubmed/30947742 http://dx.doi.org/10.1186/s40880-019-0362-z

Ejemplares similares

Generalized tree structure to annotate untargeted metabolomics and stable isotope tracing data
por: Li, Shuzhao, et al.
Publicado: (2023)

Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants
por: Doppler, Maria, et al.
Publicado: (2016)

MetExtract II: A Software Suite for Stable Isotope-Assisted Untargeted Metabolomics
por: Bueschl, Christoph, et al.
Publicado: (2017)

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments
por: Puchalska, Patrycja, et al.
Publicado: (2018)

An optimization method for untargeted MS-based isotopic tracing investigations of metabolism
por: Butin, Noémie, et al.
Publicado: (2022)

A novel stable isotope labelling assisted workflow for improved untargeted LC–HRMS based metabolomics research
por: Bueschl, Christoph, et al.
Publicado: (2013)

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
por: Creek, Darren J., et al.
Publicado: (2015)

Stable Isotope–Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation
por: Doppler, Maria, et al.
Publicado: (2019)

Melatonin enhances sorafenib-induced cytotoxicity in FLT3-ITD acute myeloid leukemia cells by redox modification
por: Tian, Tian, et al.
Publicado: (2019)

X(13)CMS: Global Tracking of Isotopic Labels in Untargeted Metabolomics
por: Huang, Xiaojing, et al.
Publicado: (2014)

Stable Isotope Tracing Metabolomics to Investigate the Metabolic Activity of Bioactive Compounds for Cancer Prevention and Treatment
por: Choudhury, Feroza K., et al.
Publicado: (2020)

Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila
por: Wang, Ruohong, et al.
Publicado: (2022)

Automated LC-HRMS(/MS) Approach for the Annotation of Fragment Ions Derived from Stable Isotope Labeling-Assisted Untargeted Metabolomics
por: Neumann, Nora K. N., et al.
Publicado: (2014)

Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells
por: Zhang, Jie, et al.
Publicado: (2023)

Stable Isotopes for Tracing Cardiac Metabolism in Diseases
por: Karlstaedt, Anja
Publicado: (2021)

Stable Isotopic Tracing—A Way Forward for Nanotechnology
por: Gulson, Brian, et al.
Publicado: (2006)

Tracing deep carbon cycling by metal stable isotopes
por: Li, Shu-Guang
Publicado: (2022)

Physiological impact of in vivo stable isotope tracing on cancer metabolism
por: Grima-Reyes, Manuel, et al.
Publicado: (2021)

Optimized protocol for stable isotope tracing and steady-state metabolomics in mouse HER2+ breast cancer brain metastasis
por: Parida, Pravat Kumar, et al.
Publicado: (2022)

Biodesulfurization Induces Reprogramming of Sulfur Metabolism in Rhodococcus qingshengii IGTS8: Proteomics and Untargeted Metabolomics
por: Hirschler, Aurélie, et al.
Publicado: (2021)

Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo
por: Liu, Xiaoxia, et al.
Publicado: (2020)

Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat
por: Kluger, Bernhard, et al.
Publicado: (2012)

Escher-Trace: a web application for pathway-based visualization of stable isotope tracing data
por: Kumar, Avi, et al.
Publicado: (2020)

Current Practice in Untargeted Human Milk Metabolomics
por: Ten-Doménech, Isabel, et al.
Publicado: (2020)

Entropy analysis of stable isotopes in precipitation: tracing the monsoon systems in China
por: Wang, Tao, et al.
Publicado: (2016)

Seasonal Cyclicity in Trace Elements and Stable Isotopes of Modern Horse Enamel
por: de Winter, Niels J., et al.
Publicado: (2016)

Biological Control of Chromium Redox and Stable Isotope Composition in the Surface Ocean
por: Janssen, David J., et al.
Publicado: (2020)

Untargeted Metabolomics Reveal Defensome-Related Metabolic Reprogramming in Sorghum bicolor against Infection by Burkholderia andropogonis
por: Mareya, Charity R., et al.
Publicado: (2019)

Untargeted and spatial-resolved metabolomics characterize serum and tissue-specific metabolic reprogramming in acute kidney injury
por: Xu, Bei, et al.
Publicado: (2023)

Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets
por: Jin, Bo, et al.
Publicado: (2023)

Metabolomics, Stable Isotopes, and A(−)β(+) Ketosis-Prone Diabetes
por: Ramos-Roman, Maria A., et al.
Publicado: (2013)

Metabolome-Wide Analysis of Stable Isotope Labeling—Is It Worth the Effort?
por: Weindl, Daniel, et al.
Publicado: (2015)

Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics
por: Srivastava, Anubhav, et al.
Publicado: (2016)

Application of Stable Isotope-Assisted Metabolomics for Cell Metabolism Studies
por: You, Le, et al.
Publicado: (2014)

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics
por: Williams, Holden C., et al.
Publicado: (2020)

Tracing the geographic origin of velvet antlers in China via stable isotope analyses
por: Zhao, Haiping, et al.
Publicado: (2022)

Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line
por: Lackner, Marcel, et al.
Publicado: (2022)

Mercury deposition and redox transformation processes in peatland constrained by mercury stable isotopes
por: Li, Chuxian, et al.
Publicado: (2023)

Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis
por: Meng-Reiterer, Jacqueline, et al.
Publicado: (2015)

Untargeted Profiling of Tracer-Derived Metabolites Using Stable Isotopic Labeling and Fast Polarity-Switching LC–ESI-HRMS
por: Kluger, Bernhard, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_uo4atm9qq24sikal1i1slda6pj