RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

BACKGROUND: GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive oncogene and is different from the classic PML-RARA in terms of therapeutic r...

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Detalles Bibliográficos
Autores principales: Yan, Wenzhe, Li, Ji, Zhang, Yang, Yin, Yafei, Cheng, Zhao, Wang, Jiayi, Hu, Guoyu, Liu, Sufang, Wang, Yewei, Xu, Yunxiao, Peng, Hongling, Zhang, Guangsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449960/
https://www.ncbi.nlm.nih.gov/pubmed/30992691
http://dx.doi.org/10.1186/s12935-019-0803-4

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