HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways

BACKGROUND: HIV-associated neurocognitive disorders (HANDs) afflict more than half of HIV-1-positive individuals. The transactivator of transcription (Tat) produced by HIV virus elicits inflammatory process and is a major neurotoxic mediator that induce neuron damage during HAND pathogenesis. Activa...

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Detalles Bibliográficos
Autores principales: Zhou, Feng, Liu, Xiaomei, Gao, Lin, Zhou, Xinxin, Cao, Qianwen, Niu, Liping, Wang, Jing, Zuo, Dongjiao, Li, Xiangyang, Yang, Ying, Hu, Minmin, Yu, Yinghua, Tang, Renxian, Lee, Bong Ho, Choi, Byoung Wook, Wang, Yugang, Izumiya, Yoshihiro, Xue, Min, Zheng, Kuiyang, Gao, Dianshuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449963/
https://www.ncbi.nlm.nih.gov/pubmed/30947729
http://dx.doi.org/10.1186/s12974-019-1466-8

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