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Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

BACKGROUND: Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with CA tubes...

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Detalles Bibliográficos
Autores principales:	Peng, Wang, Shi, Jiong, Márquez, Chantal L., Lau, Derrick, Walsh, James, Faysal, K. M. Rifat, Byeon, Chang H., Byeon, In-Ja L., Aiken, Christopher, Böcking, Till
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449974/ https://www.ncbi.nlm.nih.gov/pubmed/30947724 http://dx.doi.org/10.1186/s12977-019-0471-4

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