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An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis

BACKGROUND: Diarrheagenic Escherichia coli (DEC) is a common enteric pathogen that causes a wide spectrum of gastrointestinal infections, particularly in developing countries. This is a systematic review and meta-analysis to determine the prevalence of DEC in various geographical regions in Iran. MA...

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Autores principales: Alizade, Hesam, Hosseini Teshnizi, Saeed, Azad, Mohsen, Shojae, Saeed, Gouklani, Hamed, Davoodian, Parivash, Ghanbarpour, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450139/
https://www.ncbi.nlm.nih.gov/pubmed/31007693
http://dx.doi.org/10.4103/jrms.JRMS_256_18
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author Alizade, Hesam
Hosseini Teshnizi, Saeed
Azad, Mohsen
Shojae, Saeed
Gouklani, Hamed
Davoodian, Parivash
Ghanbarpour, Reza
author_facet Alizade, Hesam
Hosseini Teshnizi, Saeed
Azad, Mohsen
Shojae, Saeed
Gouklani, Hamed
Davoodian, Parivash
Ghanbarpour, Reza
author_sort Alizade, Hesam
collection PubMed
description BACKGROUND: Diarrheagenic Escherichia coli (DEC) is a common enteric pathogen that causes a wide spectrum of gastrointestinal infections, particularly in developing countries. This is a systematic review and meta-analysis to determine the prevalence of DEC in various geographical regions in Iran. MATERIALS AND METHODS: English (PubMed, Web of Science, Scopus, Embase, Cochrane Library, and Google Scholar) and Persian (IranMedex, SID, Magiran, and Iran Doc) databases were comprehensively searched from January 1990 to April 2017. Study selection and data extraction were performed by two independent reviewers. After assessing heterogeneity among studies, a random effects model was applied to estimate pooled prevalence. Data analyses were done with the Stata software (version 12.0). This meta-analysis was registered with PROSPERO, number CRD42017070411. RESULTS: A total of 73 studies with 18068 isolates were eligible for inclusion within the meta-analysis. The results of random effects model showed that the most prevalent DEC pathotypes were enterotoxigenic E. coli (ETEC) (16%; 95% confidence interval [CI]: 11%–23%), enteroaggregative E. coli (11%; 95% CI: 8%–15%), atypical enteropathogenic E. coli (EPEC) (11%; 95% CI: 8%–14%), Shiga toxin-producing E. coli (9%; 95% CI: 6%–13%), diffuse adherent E. coli (6%; 95% CI: 6%–12%), enteroinvasive E. coli (4%; 95% CI: 2%–6%), and typical EPEC (3%; 95% CI: 1%–5%). CONCLUSION: This study showed that DEC infections in the Iranian population have low frequency. Our data suggest that the ETEC pathotype can be regarded as one of the most important etiological agents of diarrhea in this country. However, the prevalence of DEC pathotypes is diverse in different regions of Iran.
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spelling pubmed-64501392019-04-19 An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis Alizade, Hesam Hosseini Teshnizi, Saeed Azad, Mohsen Shojae, Saeed Gouklani, Hamed Davoodian, Parivash Ghanbarpour, Reza J Res Med Sci Review Article BACKGROUND: Diarrheagenic Escherichia coli (DEC) is a common enteric pathogen that causes a wide spectrum of gastrointestinal infections, particularly in developing countries. This is a systematic review and meta-analysis to determine the prevalence of DEC in various geographical regions in Iran. MATERIALS AND METHODS: English (PubMed, Web of Science, Scopus, Embase, Cochrane Library, and Google Scholar) and Persian (IranMedex, SID, Magiran, and Iran Doc) databases were comprehensively searched from January 1990 to April 2017. Study selection and data extraction were performed by two independent reviewers. After assessing heterogeneity among studies, a random effects model was applied to estimate pooled prevalence. Data analyses were done with the Stata software (version 12.0). This meta-analysis was registered with PROSPERO, number CRD42017070411. RESULTS: A total of 73 studies with 18068 isolates were eligible for inclusion within the meta-analysis. The results of random effects model showed that the most prevalent DEC pathotypes were enterotoxigenic E. coli (ETEC) (16%; 95% confidence interval [CI]: 11%–23%), enteroaggregative E. coli (11%; 95% CI: 8%–15%), atypical enteropathogenic E. coli (EPEC) (11%; 95% CI: 8%–14%), Shiga toxin-producing E. coli (9%; 95% CI: 6%–13%), diffuse adherent E. coli (6%; 95% CI: 6%–12%), enteroinvasive E. coli (4%; 95% CI: 2%–6%), and typical EPEC (3%; 95% CI: 1%–5%). CONCLUSION: This study showed that DEC infections in the Iranian population have low frequency. Our data suggest that the ETEC pathotype can be regarded as one of the most important etiological agents of diarrhea in this country. However, the prevalence of DEC pathotypes is diverse in different regions of Iran. Wolters Kluwer - Medknow 2019-03-25 /pmc/articles/PMC6450139/ /pubmed/31007693 http://dx.doi.org/10.4103/jrms.JRMS_256_18 Text en Copyright: © 2019 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Alizade, Hesam
Hosseini Teshnizi, Saeed
Azad, Mohsen
Shojae, Saeed
Gouklani, Hamed
Davoodian, Parivash
Ghanbarpour, Reza
An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis
title An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis
title_full An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis
title_fullStr An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis
title_full_unstemmed An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis
title_short An overview of diarrheagenic Escherichia coli in Iran: A systematic review and meta-analysis
title_sort overview of diarrheagenic escherichia coli in iran: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450139/
https://www.ncbi.nlm.nih.gov/pubmed/31007693
http://dx.doi.org/10.4103/jrms.JRMS_256_18
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