Standard operating procedure for somatic variant refinement of sequencing data with paired tumor and normal samples

PURPOSE: Following automated variant calling, manual review of aligned read sequences is required to identify a high-quality list of somatic variants. Despite widespread use in analyzing sequence data, methods to standardize manual review have not been described, resulting in high inter- and intrala...

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Detalles Bibliográficos
Autores principales: Barnell, Erica K., Ronning, Peter, Campbell, Katie M., Krysiak, Kilannin, Ainscough, Benjamin J., Sheta, Lana M., Pema, Shahil P., Schmidt, Alina D., Richters, Megan, Cotto, Kelsy C., Danos, Arpad M., Ramirez, Cody, Skidmore, Zachary L., Spies, Nicholas C., Hundal, Jasreet, Sediqzad, Malik S., Kunisaki, Jason, Gomez, Felicia, Trani, Lee, Matlock, Matthew, Wagner, Alex H., Swamidass, S. Joshua, Griffith, Malachi, Griffith, Obi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450397/
https://www.ncbi.nlm.nih.gov/pubmed/30287923
http://dx.doi.org/10.1038/s41436-018-0278-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450397/
https://www.ncbi.nlm.nih.gov/pubmed/30287923
http://dx.doi.org/10.1038/s41436-018-0278-z

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