Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets

The potential of CRISPR–Cas9-based therapeutic genome editing is hampered by difficulties in the control of the in vivo activity of CRISPR–Cas9. To minimize any genotoxicity, precise activation of CRISPR–Cas9 in the target tissue is desirable. Here, we show that, by complexing magnetic nanoparticles...

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Detalles Bibliográficos
Autores principales: Zhu, Haibao, Zhang, Linlin, Tong, Sheng, Lee, Ciaran, Deshmukh, Harshavardhan, Bao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450418/
https://www.ncbi.nlm.nih.gov/pubmed/30944431
http://dx.doi.org/10.1038/s41551-018-0318-7

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