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Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization

The human membrane-bound α/β-hydrolase domain 6 (ABHD6) protein modulates endocannabinoid signaling, which controls appetite, pain and learning, as well as being linked to Alzheimer’s and Parkinson’s diseases, through the degradation of the key lipid messenger 2-arachidonylglycerol (2-AG). This make...

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Detalles Bibliográficos
Autores principales: Bleffert, Florian, Granzin, Joachim, Gohlke, Holger, Batra-Safferling, Renu, Jaeger, Karl-Erich, Kovacic, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450514/
https://www.ncbi.nlm.nih.gov/pubmed/30950828
http://dx.doi.org/10.1107/S2053230X19002152