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Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients

People with Down syndrome (DS) are at high risk of developing Alzheimer disease (AD) with aging. The diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. Plasma neurofilament light chain (NfL) is one of the established biomarkers of AD, suggesting that it may be useful...

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Autores principales: Shinomoto, Makiko, Kasai, Takashi, Tatebe, Harutsugu, Kondo, Masaki, Ohmichi, Takuma, Morimoto, Masafumi, Chiyonobu, Tomohiro, Terada, Naoto, Allsop, David, Yokota, Isao, Mizuno, Toshiki, Tokuda, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450630/
https://www.ncbi.nlm.nih.gov/pubmed/30951523
http://dx.doi.org/10.1371/journal.pone.0211575
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author Shinomoto, Makiko
Kasai, Takashi
Tatebe, Harutsugu
Kondo, Masaki
Ohmichi, Takuma
Morimoto, Masafumi
Chiyonobu, Tomohiro
Terada, Naoto
Allsop, David
Yokota, Isao
Mizuno, Toshiki
Tokuda, Takahiko
author_facet Shinomoto, Makiko
Kasai, Takashi
Tatebe, Harutsugu
Kondo, Masaki
Ohmichi, Takuma
Morimoto, Masafumi
Chiyonobu, Tomohiro
Terada, Naoto
Allsop, David
Yokota, Isao
Mizuno, Toshiki
Tokuda, Takahiko
author_sort Shinomoto, Makiko
collection PubMed
description People with Down syndrome (DS) are at high risk of developing Alzheimer disease (AD) with aging. The diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. Plasma neurofilament light chain (NfL) is one of the established biomarkers of AD, suggesting that it may be useful as an indicator of dementia in DS patients. The aims of this study were: 1) to examine whether plasma levels of NfL in DS patients are correlated with decreased adaptive behavior scores one year after sample collection, and 2) to compare plasma levels of NfL in adults with DS and an age-matched healthy control population. In this study, plasma levels of NfL in 24 patients with DS and 24 control participants were measured by the single-molecule immunoarray (Simoa) method. We observed significantly increased plasma NfL levels in the DS compared with the control group. There was a significant correlation between age and levels of plasma NfL in both groups. This age-dependent elevation was steeper in the DS compared with the control group. Moreover, elevated plasma NfL was associated with decreased adaptive behavior scores one year later, after age-adjustment. Previously reported blood-based biomarkers available in Simoa for DS, plasma total tau and phosphorylated tau, were not significantly correlated with the annual decrement of adaptive behavior scores after age-adjustment. These results suggest that plasma NfL has the potential to serve as an objective biomarker to predict dementia in adult DS patients.
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spelling pubmed-64506302019-04-19 Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients Shinomoto, Makiko Kasai, Takashi Tatebe, Harutsugu Kondo, Masaki Ohmichi, Takuma Morimoto, Masafumi Chiyonobu, Tomohiro Terada, Naoto Allsop, David Yokota, Isao Mizuno, Toshiki Tokuda, Takahiko PLoS One Research Article People with Down syndrome (DS) are at high risk of developing Alzheimer disease (AD) with aging. The diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. Plasma neurofilament light chain (NfL) is one of the established biomarkers of AD, suggesting that it may be useful as an indicator of dementia in DS patients. The aims of this study were: 1) to examine whether plasma levels of NfL in DS patients are correlated with decreased adaptive behavior scores one year after sample collection, and 2) to compare plasma levels of NfL in adults with DS and an age-matched healthy control population. In this study, plasma levels of NfL in 24 patients with DS and 24 control participants were measured by the single-molecule immunoarray (Simoa) method. We observed significantly increased plasma NfL levels in the DS compared with the control group. There was a significant correlation between age and levels of plasma NfL in both groups. This age-dependent elevation was steeper in the DS compared with the control group. Moreover, elevated plasma NfL was associated with decreased adaptive behavior scores one year later, after age-adjustment. Previously reported blood-based biomarkers available in Simoa for DS, plasma total tau and phosphorylated tau, were not significantly correlated with the annual decrement of adaptive behavior scores after age-adjustment. These results suggest that plasma NfL has the potential to serve as an objective biomarker to predict dementia in adult DS patients. Public Library of Science 2019-04-05 /pmc/articles/PMC6450630/ /pubmed/30951523 http://dx.doi.org/10.1371/journal.pone.0211575 Text en © 2019 Shinomoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shinomoto, Makiko
Kasai, Takashi
Tatebe, Harutsugu
Kondo, Masaki
Ohmichi, Takuma
Morimoto, Masafumi
Chiyonobu, Tomohiro
Terada, Naoto
Allsop, David
Yokota, Isao
Mizuno, Toshiki
Tokuda, Takahiko
Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
title Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
title_full Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
title_fullStr Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
title_full_unstemmed Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
title_short Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients
title_sort plasma neurofilament light chain: a potential prognostic biomarker of dementia in adult down syndrome patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450630/
https://www.ncbi.nlm.nih.gov/pubmed/30951523
http://dx.doi.org/10.1371/journal.pone.0211575
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