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An amygdalar neural ensemble that encodes the unpleasantness of pain
Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450685/ https://www.ncbi.nlm.nih.gov/pubmed/30655440 http://dx.doi.org/10.1126/science.aap8586 |
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author | Corder, Gregory Ahanonu, Biafra Grewe, Benjamin F. Wang, Dong Schnitzer, Mark J. Scherrer, Grégory |
author_facet | Corder, Gregory Ahanonu, Biafra Grewe, Benjamin F. Wang, Dong Schnitzer, Mark J. Scherrer, Grégory |
author_sort | Corder, Gregory |
collection | PubMed |
description | Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimuli, withdrawal reflexes, anxiety, or reward. Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to drive dysfunctional perceptual changes associated with neuropathic pain, including pain aversion to light touch (allodynia). These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception. |
format | Online Article Text |
id | pubmed-6450685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64506852019-04-05 An amygdalar neural ensemble that encodes the unpleasantness of pain Corder, Gregory Ahanonu, Biafra Grewe, Benjamin F. Wang, Dong Schnitzer, Mark J. Scherrer, Grégory Science Neuroscience Pain is an unpleasant experience. How the brain’s affective neural circuits attribute this aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo calcium imaging and neural activity manipulation in freely behaving mice encountering noxious stimuli, we identified a distinct neural ensemble in the basolateral amygdala that encodes the negative affective valence of pain. Silencing this nociceptive ensemble alleviated pain affective-motivational behaviors without altering the detection of noxious stimuli, withdrawal reflexes, anxiety, or reward. Following peripheral nerve injury, innocuous stimuli activated this nociceptive ensemble to drive dysfunctional perceptual changes associated with neuropathic pain, including pain aversion to light touch (allodynia). These results identify the amygdalar representations of noxious stimuli that are functionally required for the negative affective qualities of acute and chronic pain perception. American Association for the Advancement of Science 2018-01-18 2019 /pmc/articles/PMC6450685/ /pubmed/30655440 http://dx.doi.org/10.1126/science.aap8586 Text en © 2019, American Association for the Advancement of Science https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroscience Corder, Gregory Ahanonu, Biafra Grewe, Benjamin F. Wang, Dong Schnitzer, Mark J. Scherrer, Grégory An amygdalar neural ensemble that encodes the unpleasantness of pain |
title | An amygdalar neural ensemble that encodes the unpleasantness of pain |
title_full | An amygdalar neural ensemble that encodes the unpleasantness of pain |
title_fullStr | An amygdalar neural ensemble that encodes the unpleasantness of pain |
title_full_unstemmed | An amygdalar neural ensemble that encodes the unpleasantness of pain |
title_short | An amygdalar neural ensemble that encodes the unpleasantness of pain |
title_sort | amygdalar neural ensemble that encodes the unpleasantness of pain |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450685/ https://www.ncbi.nlm.nih.gov/pubmed/30655440 http://dx.doi.org/10.1126/science.aap8586 |
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