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In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery

Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticle...

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Detalles Bibliográficos
Autores principales: Park, Suehyun, Song, Jeongeun, Kim, Jun Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450686/
https://www.ncbi.nlm.nih.gov/pubmed/30972363
http://dx.doi.org/10.1126/sciadv.aav4943
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author Park, Suehyun
Song, Jeongeun
Kim, Jun Soo
author_facet Park, Suehyun
Song, Jeongeun
Kim, Jun Soo
author_sort Park, Suehyun
collection PubMed
description Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticles in which nanoparticle delivery follows the path dictated by a single, long, double-stranded DNA. We performed Brownian dynamics simulations to prove its realization using coarse-grained models. A periodic and asymmetric potential for nanoparticle binding is constructed along a single, long, double-stranded DNA molecule by a novel strategy that uses variation in sequence-dependent DNA flexibility. Directional and processive motion of nanoparticles is achieved by changing salt concentration repetitively over several cycles to switch the asymmetric potential on and off. This work suggests that double-stranded DNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications.
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spelling pubmed-64506862019-04-10 In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery Park, Suehyun Song, Jeongeun Kim, Jun Soo Sci Adv Research Articles Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticles in which nanoparticle delivery follows the path dictated by a single, long, double-stranded DNA. We performed Brownian dynamics simulations to prove its realization using coarse-grained models. A periodic and asymmetric potential for nanoparticle binding is constructed along a single, long, double-stranded DNA molecule by a novel strategy that uses variation in sequence-dependent DNA flexibility. Directional and processive motion of nanoparticles is achieved by changing salt concentration repetitively over several cycles to switch the asymmetric potential on and off. This work suggests that double-stranded DNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications. American Association for the Advancement of Science 2019-04-05 /pmc/articles/PMC6450686/ /pubmed/30972363 http://dx.doi.org/10.1126/sciadv.aav4943 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Park, Suehyun
Song, Jeongeun
Kim, Jun Soo
In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
title In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
title_full In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
title_fullStr In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
title_full_unstemmed In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
title_short In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
title_sort in silico construction of a flexibility-based dna brownian ratchet for directional nanoparticle delivery
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450686/
https://www.ncbi.nlm.nih.gov/pubmed/30972363
http://dx.doi.org/10.1126/sciadv.aav4943
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