Cargando…
In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticle...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450686/ https://www.ncbi.nlm.nih.gov/pubmed/30972363 http://dx.doi.org/10.1126/sciadv.aav4943 |
_version_ | 1783409063259799552 |
---|---|
author | Park, Suehyun Song, Jeongeun Kim, Jun Soo |
author_facet | Park, Suehyun Song, Jeongeun Kim, Jun Soo |
author_sort | Park, Suehyun |
collection | PubMed |
description | Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticles in which nanoparticle delivery follows the path dictated by a single, long, double-stranded DNA. We performed Brownian dynamics simulations to prove its realization using coarse-grained models. A periodic and asymmetric potential for nanoparticle binding is constructed along a single, long, double-stranded DNA molecule by a novel strategy that uses variation in sequence-dependent DNA flexibility. Directional and processive motion of nanoparticles is achieved by changing salt concentration repetitively over several cycles to switch the asymmetric potential on and off. This work suggests that double-stranded DNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications. |
format | Online Article Text |
id | pubmed-6450686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64506862019-04-10 In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery Park, Suehyun Song, Jeongeun Kim, Jun Soo Sci Adv Research Articles Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticles in which nanoparticle delivery follows the path dictated by a single, long, double-stranded DNA. We performed Brownian dynamics simulations to prove its realization using coarse-grained models. A periodic and asymmetric potential for nanoparticle binding is constructed along a single, long, double-stranded DNA molecule by a novel strategy that uses variation in sequence-dependent DNA flexibility. Directional and processive motion of nanoparticles is achieved by changing salt concentration repetitively over several cycles to switch the asymmetric potential on and off. This work suggests that double-stranded DNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications. American Association for the Advancement of Science 2019-04-05 /pmc/articles/PMC6450686/ /pubmed/30972363 http://dx.doi.org/10.1126/sciadv.aav4943 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Park, Suehyun Song, Jeongeun Kim, Jun Soo In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery |
title | In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery |
title_full | In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery |
title_fullStr | In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery |
title_full_unstemmed | In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery |
title_short | In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery |
title_sort | in silico construction of a flexibility-based dna brownian ratchet for directional nanoparticle delivery |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450686/ https://www.ncbi.nlm.nih.gov/pubmed/30972363 http://dx.doi.org/10.1126/sciadv.aav4943 |
work_keys_str_mv | AT parksuehyun insilicoconstructionofaflexibilitybaseddnabrownianratchetfordirectionalnanoparticledelivery AT songjeongeun insilicoconstructionofaflexibilitybaseddnabrownianratchetfordirectionalnanoparticledelivery AT kimjunsoo insilicoconstructionofaflexibilitybaseddnabrownianratchetfordirectionalnanoparticledelivery |