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Distinct bone marrow blood vessels differentially regulate hematopoiesis

Bone marrow (BM) endothelial cells (BMECs) form a network of blood vessels (BVs) which regulate both leukocyte trafficking and hematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles and if these events occur at the same vascular site. W...

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Autores principales: Itkin, Tomer, Gur-Cohen, Shiri, Spencer, Joel A., Schajnovitz, Amir, Ramasamy, Saravana K., Kusumbe, Anjali P., Ledergor, Guy, Jung, Yookyung, Milo, Idan, Poulos, Michael G., Kalinkovich, Alexander, Ludin, Aya, Kollet, Orit, Shakhar, Guy, Butler, Jason M., Rafii, Shahin, Adams, Ralf H., Scadden, David T., Lin, Charles P., Lapidot, Tsvee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450701/
https://www.ncbi.nlm.nih.gov/pubmed/27074509
http://dx.doi.org/10.1038/nature17624
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author Itkin, Tomer
Gur-Cohen, Shiri
Spencer, Joel A.
Schajnovitz, Amir
Ramasamy, Saravana K.
Kusumbe, Anjali P.
Ledergor, Guy
Jung, Yookyung
Milo, Idan
Poulos, Michael G.
Kalinkovich, Alexander
Ludin, Aya
Kollet, Orit
Shakhar, Guy
Butler, Jason M.
Rafii, Shahin
Adams, Ralf H.
Scadden, David T.
Lin, Charles P.
Lapidot, Tsvee
author_facet Itkin, Tomer
Gur-Cohen, Shiri
Spencer, Joel A.
Schajnovitz, Amir
Ramasamy, Saravana K.
Kusumbe, Anjali P.
Ledergor, Guy
Jung, Yookyung
Milo, Idan
Poulos, Michael G.
Kalinkovich, Alexander
Ludin, Aya
Kollet, Orit
Shakhar, Guy
Butler, Jason M.
Rafii, Shahin
Adams, Ralf H.
Scadden, David T.
Lin, Charles P.
Lapidot, Tsvee
author_sort Itkin, Tomer
collection PubMed
description Bone marrow (BM) endothelial cells (BMECs) form a network of blood vessels (BVs) which regulate both leukocyte trafficking and hematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles and if these events occur at the same vascular site. We found that BM stem cell maintenance and leukocyte trafficking are regulated by distinct BV types with different permeability properties. Less permeable arterial BVs maintain HSCs in a low reactive oxygen species (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive site for immature and mature leukocyte trafficking to and from the BM. A functional consequence of high BVs permeability is that exposure to blood plasma increases BM HSPC ROS levels, augmenting their migration capacity while compromising their long term repopulation and survival potential. These findings may have relevance for clinical hematopoietic stem cell transplantation and mobilization protocols.
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spelling pubmed-64507012019-04-05 Distinct bone marrow blood vessels differentially regulate hematopoiesis Itkin, Tomer Gur-Cohen, Shiri Spencer, Joel A. Schajnovitz, Amir Ramasamy, Saravana K. Kusumbe, Anjali P. Ledergor, Guy Jung, Yookyung Milo, Idan Poulos, Michael G. Kalinkovich, Alexander Ludin, Aya Kollet, Orit Shakhar, Guy Butler, Jason M. Rafii, Shahin Adams, Ralf H. Scadden, David T. Lin, Charles P. Lapidot, Tsvee Nature Article Bone marrow (BM) endothelial cells (BMECs) form a network of blood vessels (BVs) which regulate both leukocyte trafficking and hematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles and if these events occur at the same vascular site. We found that BM stem cell maintenance and leukocyte trafficking are regulated by distinct BV types with different permeability properties. Less permeable arterial BVs maintain HSCs in a low reactive oxygen species (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive site for immature and mature leukocyte trafficking to and from the BM. A functional consequence of high BVs permeability is that exposure to blood plasma increases BM HSPC ROS levels, augmenting their migration capacity while compromising their long term repopulation and survival potential. These findings may have relevance for clinical hematopoietic stem cell transplantation and mobilization protocols. 2016-04-13 2016-04-21 /pmc/articles/PMC6450701/ /pubmed/27074509 http://dx.doi.org/10.1038/nature17624 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Itkin, Tomer
Gur-Cohen, Shiri
Spencer, Joel A.
Schajnovitz, Amir
Ramasamy, Saravana K.
Kusumbe, Anjali P.
Ledergor, Guy
Jung, Yookyung
Milo, Idan
Poulos, Michael G.
Kalinkovich, Alexander
Ludin, Aya
Kollet, Orit
Shakhar, Guy
Butler, Jason M.
Rafii, Shahin
Adams, Ralf H.
Scadden, David T.
Lin, Charles P.
Lapidot, Tsvee
Distinct bone marrow blood vessels differentially regulate hematopoiesis
title Distinct bone marrow blood vessels differentially regulate hematopoiesis
title_full Distinct bone marrow blood vessels differentially regulate hematopoiesis
title_fullStr Distinct bone marrow blood vessels differentially regulate hematopoiesis
title_full_unstemmed Distinct bone marrow blood vessels differentially regulate hematopoiesis
title_short Distinct bone marrow blood vessels differentially regulate hematopoiesis
title_sort distinct bone marrow blood vessels differentially regulate hematopoiesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450701/
https://www.ncbi.nlm.nih.gov/pubmed/27074509
http://dx.doi.org/10.1038/nature17624
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