Cargando…

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

OBJECTIVE: To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS). METHODS: Linkage disequilibrium score regression and Mendelian randomization were applied in a large‐scale, data‐driven manner to explore genetic correlations and causal relationships between...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bandres‐Ciga, Sara, Noyce, Alastair J., Hemani, Gibran, Nicolas, Aude, Calvo, Andrea, Mora, Gabriele, Tienari, Pentti J., Stone, David J., Nalls, Mike A., Singleton, Andrew B., Chiò, Adriano, Traynor, Bryan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450729/ https://www.ncbi.nlm.nih.gov/pubmed/30723964 http://dx.doi.org/10.1002/ana.25431

Ejemplares similares

Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
por: Liu, Hui, et al.
Publicado: (2022)

A population scale analysis of rare SNCA variation in the UK Biobank
por: Blauwendraat, Cornelis, et al.
Publicado: (2020)

Mendelian randomization: genetic anchors for causal inference in epidemiological studies
por: Davey Smith, George, et al.
Publicado: (2014)

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
por: Saez-Atienzar, Sara, et al.
Publicado: (2021)

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
por: Richardson, Tom G, et al.
Publicado: (2019)

Unhealthy Behaviours and Risk of Parkinson’s Disease: A Mendelian Randomisation Study
por: Heilbron, Karl, et al.
Publicado: (2021)

Age-related penetrance of the C9orf72 repeat expansion
por: Murphy, Natalie A., et al.
Publicado: (2017)

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
por: Noyce, Alastair J., et al.
Publicado: (2017)

Bidirectional relationship between olfaction and Parkinson’s disease
por: Kim, Jonggeol J., et al.
Publicado: (2023)

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040
por: Arthur, Karissa C., et al.
Publicado: (2016)

Evaluating Lipid‐Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization
por: Williams, Dylan M., et al.
Publicado: (2020)

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
por: Bandres-Ciga, S., et al.
Publicado: (2020)

Correction to: Large‑scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
por: Bandres-Ciga, S., et al.
Publicado: (2021)

The Parkinson's Disease Mendelian Randomization Research Portal
por: Noyce, Alastair J., et al.
Publicado: (2019)

Mendelian Randomization Study Shows No Causal Relationship Between Circulating Urate Levels and Parkinson’s Disease
por: Kia, Demis A., et al.
Publicado: (2018)

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments
por: Wang, Jingshu, et al.
Publicado: (2021)

Parkinson’s disease determinants, prediction and gene–environment interactions in the UK Biobank
por: Jacobs, Benjamin Meir, et al.
Publicado: (2020)

Untangling the knot: Lifetime physical exercise and amyotrophic lateral sclerosis
por: Chiò, Adriano, et al.
Publicado: (2021)

Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study
por: Kang, Xiaoying, et al.
Publicado: (2021)

Lower Lymphocyte Count is Associated With Increased Risk of Parkinson’s Disease
por: Jensen, Melanie P., et al.
Publicado: (2021)

Analysis of rare Parkinson’s disease variants in millions of people
por: Pitz, Vanessa, et al.
Publicado: (2023)

Effect Modification between Genes and Environment and Parkinson's Disease Risk
por: Periñán, Maria Teresa, et al.
Publicado: (2022)

Causal Inference of Genetic Variants and Genes in Amyotrophic Lateral Sclerosis
por: Pan, Siyu, et al.
Publicado: (2022)

Mendelian Randomization — the Key to Understanding Aspects of Parkinson's Disease Causation?
por: Noyce, Alastair J., et al.
Publicado: (2015)

Association of polygenic risk score with response to deep brain stimulation in Parkinson’s disease
por: Yoon, Esther, et al.
Publicado: (2023)

Type 2 Diabetes as a Determinant of Parkinson’s Disease Risk and Progression
por: Chohan, Harneek, et al.
Publicado: (2021)

Orienting the causal relationship between imprecisely measured traits using GWAS summary data
por: Hemani, Gibran, et al.
Publicado: (2017)

Correction: Orienting the causal relationship between imprecisely measured traits using GWAS summary data
por: Hemani, Gibran, et al.
Publicado: (2017)

ALS in Finland: Major Genetic Variants and Clinical Characteristics of Patients With and Without the C9orf72 Hexanucleotide Repeat Expansion
por: Laaksovirta, Hannu, et al.
Publicado: (2022)

Identification and prediction of Parkinson’s disease subtypes and progression using machine learning in two cohorts
por: Dadu, Anant, et al.
Publicado: (2022)

The MR-Base platform supports systematic causal inference across the human phenome
por: Hemani, Gibran, et al.
Publicado: (2018)

Black and African American Connections to Parkinson's Disease Study: Addressing Missing Diversity in Parkinson's Disease Genetics
por: Bandres‐Ciga, Sara
Publicado: (2022)

Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry
por: Li, Yao, et al.
Publicado: (2022)

Phenotype Analysis of Fused in Sarcoma Mutations in Amyotrophic Lateral Sclerosis
por: Grassano, Maurizio, et al.
Publicado: (2022)

TDP-43 Is Not a Common Cause of Sporadic Amyotrophic Lateral Sclerosis
por: Guerreiro, Rita J., et al.
Publicado: (2008)

Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis
por: D’Antona, Salvatore, et al.
Publicado: (2023)

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
por: Johnson, Janel O., et al.
Publicado: (2014)

Response to the letter by de Boer et al. (2022)
por: Kaivola, Karri, et al.
Publicado: (2022)

BMI and low vitamin D are causal factors for multiple sclerosis: A Mendelian Randomization study
por: Jacobs, Benjamin M., et al.
Publicado: (2020)

Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+)
por: Mäkelä, Mira, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gk7g17nd9jms2g24qvemeq3vf6