ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition

There is increasing evidence that genomic instability is a prerequisite for cancer progression. Here we show that SIM2s, a member of the bHLH/PAS family of transcription factors, regulates DNA damage repair through enhancement of homologous recombination, and prevents epithelial mesenchymal transiti...

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Detalles Bibliográficos
Autores principales: Pearson, Scott J., Sarkar, Tapasree Roy, McQueen, Cole M., Elswood, Jessica, Schmitt, Emily E., Wall, Steven W., Scribner, Kelly C., Wyatt, Garhett, Barhoumi, Rola, Behbod, Fariba, Rijnkels, Monique, Porter, Weston W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450754/
https://www.ncbi.nlm.nih.gov/pubmed/30531838
http://dx.doi.org/10.1038/s41388-018-0622-4

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