Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients

Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) in the NS5A region impair the efficacy of NS5A inhibitors. In this study, we evaluated the characteristics of the novel RASs observed in treatment-failure patients, A92K and a deletion at P32 (P32del), and the susceptibility of vi...

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Detalles Bibliográficos
Autores principales: Nitta, Sayuri, Asahina, Yasuhiro, Kato, Takanobu, Tsuchiya, Jun, Inoue-Shinomiya, Emi, Sato, Ayako, Tsunoda, Tomoyuki, Miyoshi, Masato, Kawai-Kitahata, Fukiko, Murakawa, Miyako, Itsui, Yasuhiro, Nakagawa, Mina, Azuma, Seishin, Kakinuma, Sei, Hikita, Hayato, Takehara, Tetsuo, Watanabe, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450881/
https://www.ncbi.nlm.nih.gov/pubmed/30952914
http://dx.doi.org/10.1038/s41598-019-42114-z

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