N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA(165)-dependent neovascularization

The proteoglycan Syndecan-2 (Sdc2) has been implicated in regulation of cytoskeleton organization, integrin signaling and developmental angiogenesis in zebrafish. Here we report that mice with global and inducible endothelial-specific deletion of Sdc2 display marked angiogenic and arteriogenic defec...

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Detalles Bibliográficos
Autores principales: Corti, Federico, Wang, Yingdi, Rhodes, John M., Atri, Deepak, Archer-Hartmann, Stephanie, Zhang, Jiasheng, Zhuang, Zhen W., Chen, Dongying, Wang, Tianyun, Wang, Zhirui, Azadi, Parastoo, Simons, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450910/
https://www.ncbi.nlm.nih.gov/pubmed/30952866
http://dx.doi.org/10.1038/s41467-019-09605-z

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