Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics

Disrupting microtubule dynamics with spindle poisons activates the spindle-assembly checkpoint (SAC) and induces mitotic cell death. However, mitotic exit can occur prematurely without proper chromosomal segregation or cytokinesis by a process termed mitotic slippage. It remains controversial whethe...

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Detalles Bibliográficos
Autores principales: Zeng, Xiaofang, Xu, Wendy Kaichun, Lok, Tsun Ming, Ma, Hoi Tang, Poon, Randy Y. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450912/
https://www.ncbi.nlm.nih.gov/pubmed/30952840
http://dx.doi.org/10.1038/s41419-019-1539-8

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