Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection

Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(...

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Detalles Bibliográficos
Autores principales: Macchione, Micaela A., Guerrero-Beltrán, Carlos, Rosso, Anabella P., Euti, Esteban M., Martinelli, Marisa, Strumia, Miriam C., Muñoz-Fernández, Maria Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450967/
https://www.ncbi.nlm.nih.gov/pubmed/30952921
http://dx.doi.org/10.1038/s41598-019-42150-9
Descripción
Sumario:Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.

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