Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection

Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(...

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Autores principales: Macchione, Micaela A., Guerrero-Beltrán, Carlos, Rosso, Anabella P., Euti, Esteban M., Martinelli, Marisa, Strumia, Miriam C., Muñoz-Fernández, Maria Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450967/
https://www.ncbi.nlm.nih.gov/pubmed/30952921
http://dx.doi.org/10.1038/s41598-019-42150-9
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author Macchione, Micaela A.
Guerrero-Beltrán, Carlos
Rosso, Anabella P.
Euti, Esteban M.
Martinelli, Marisa
Strumia, Miriam C.
Muñoz-Fernández, Maria Ángeles
author_facet Macchione, Micaela A.
Guerrero-Beltrán, Carlos
Rosso, Anabella P.
Euti, Esteban M.
Martinelli, Marisa
Strumia, Miriam C.
Muñoz-Fernández, Maria Ángeles
author_sort Macchione, Micaela A.
collection PubMed
description Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.
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spelling pubmed-64509672019-04-11 Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection Macchione, Micaela A. Guerrero-Beltrán, Carlos Rosso, Anabella P. Euti, Esteban M. Martinelli, Marisa Strumia, Miriam C. Muñoz-Fernández, Maria Ángeles Sci Rep Article Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells. Nature Publishing Group UK 2019-04-05 /pmc/articles/PMC6450967/ /pubmed/30952921 http://dx.doi.org/10.1038/s41598-019-42150-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Macchione, Micaela A.
Guerrero-Beltrán, Carlos
Rosso, Anabella P.
Euti, Esteban M.
Martinelli, Marisa
Strumia, Miriam C.
Muñoz-Fernández, Maria Ángeles
Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
title Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
title_full Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
title_fullStr Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
title_full_unstemmed Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
title_short Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection
title_sort poly(n-vinylcaprolactam) nanogels with antiviral behavior against hiv-1 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450967/
https://www.ncbi.nlm.nih.gov/pubmed/30952921
http://dx.doi.org/10.1038/s41598-019-42150-9
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