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A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest

The Topo2a-dependent arrest is associated with faithful segregation of sister chromatids and has been identified as dysfunctional in numerous tumour cell lines. This genome-protecting pathway is poorly understood and its characterization is of significant interest, potentially offering interventiona...

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Detalles Bibliográficos
Autores principales:	Deiss, Katharina, Lockwood, Nicola, Howell, Michael, Segeren, Hendrika Alida, Saunders, Rebecca E, Chakravarty, Probir, Soliman, Tanya N, Martini, Silvia, Rocha, Nuno, Semple, Robert, Zalmas, Lykourgos-Panagiotis, Parker, Peter J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451093/ https://www.ncbi.nlm.nih.gov/pubmed/30590722 http://dx.doi.org/10.1093/nar/gky1295

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