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Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant

Proper repair of oxidatively damaged DNA bases is essential to maintain genome stability. 8-Oxoguanine (7,8-dihydro-8-oxoguanine, 8-oxoG) is a dangerous DNA lesion because it can mispair with adenine (A) during replication resulting in guanine to thymine transversion mutations. MUTYH DNA glycosylase...

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Detalles Bibliográficos
Autores principales:	Nelson, Shane R, Kathe, Scott D, Hilzinger, Thomas S, Averill, April M, Warshaw, David M, Wallace, Susan S, Lee, Andrea J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451117/ https://www.ncbi.nlm.nih.gov/pubmed/30698731 http://dx.doi.org/10.1093/nar/gkz045

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