The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

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P53-binding protein 1 (53BP1) mediates DNA repair pathway choice and promotes checkpoint activation. Chromatin marks induced by DNA double-strand breaks and recognized by 53BP1 enable focal accumulation of this multifunctional repair factor at damaged chromatin. Here, we unveil an additional level o...

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Detalles Bibliográficos
Autores principales: Salvador Moreno, Naike, Liu, Jing, Haas, Karen M, Parker, Laurie L, Chakraborty, Chaitali, Kron, Stephen J, Hodges, Kurt, Miller, Lance D, Langefeld, Carl, Robinson, Paul J, Lelièvre, Sophie A, Vidi, Pierre-Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451129/
https://www.ncbi.nlm.nih.gov/pubmed/30812030
http://dx.doi.org/10.1093/nar/gkz138
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