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Evidence for a bind-then-bend mechanism for architectural DNA binding protein yNhp6A

The yeast Nhp6A protein (yNhp6A) is a member of the eukaryotic HMGB family of chromatin factors that enhance apparent DNA flexibility. yNhp6A binds DNA nonspecifically with nM affinity, sharply bending DNA by >60°. It is not known whether the protein binds to unbent DNA and then deforms it, or if...

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Detalles Bibliográficos
Autores principales:	Sarangi, Manas Kumar, Zvoda, Viktoriya, Holte, Molly Nelson, Becker, Nicole A, Peters, Justin P, Maher, L James, Ansari, Anjum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451137/ https://www.ncbi.nlm.nih.gov/pubmed/30698746 http://dx.doi.org/10.1093/nar/gkz022

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