Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction

Hypertension and abdominal aortic aneurysm (AAA) are severe cardiovascular diseases with incompletely defined molecular mechanisms. In the current study we generated dihydrofolate reductase (DHFR) knockout mice for the first time to examine its potential contribution to the development of hypertensi...

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Detalles Bibliográficos
Autores principales: Li, Qiang, Youn, Ji Youn, Siu, Kin Lung, Murugesan, Priya, Zhang, Yixuan, Cai, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451172/
https://www.ncbi.nlm.nih.gov/pubmed/30954686
http://dx.doi.org/10.1016/j.redox.2019.101185

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