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Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload

BACKGROUND: Volume overload (VO) of isolated mitral regurgitation (MR) or aortocaval fistula (ACF) is associated with extracellular matrix degradation and cardiomyocyte myofibrillar and desmin breakdown. Left ventricular (LV) chymase activity is increased in VO and recent studies demonstrate chymase...

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Detalles Bibliográficos
Autores principales:	Powell, Pamela C., Wei, Chih-Chang, Fu, Lianwu, Pat, Betty, Bradley, Wayne E., Collawn, James F., Dell'Italia, Louis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451194/ https://www.ncbi.nlm.nih.gov/pubmed/30997426 http://dx.doi.org/10.1016/j.heliyon.2019.e01397

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