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The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers
The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451295/ https://www.ncbi.nlm.nih.gov/pubmed/30954079 http://dx.doi.org/10.1186/s12943-019-0985-3 |
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author | Xie, Changqing Ji, Ning Tang, Zhangui Li, Jing Chen, Qianming |
author_facet | Xie, Changqing Ji, Ning Tang, Zhangui Li, Jing Chen, Qianming |
author_sort | Xie, Changqing |
collection | PubMed |
description | The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information transfer in the TME. Initially considered "garbage dumpsters" and later referred to as "signal boxes", EVs carry "cargo" (proteins, lipids, or nucleic acids) that can redirect the function of a recipient cell. Currently, the molecular mechanisms and clinical applications of EVs in head and neck cancers (HNCs) are still at an early stage and need to be further investigate. In this review, we provide insight into the TME of HNCs, classifying and summarizing EVs derived from different cell types and illuminating their complex signaling networks involved in mediating tumor proliferation, invasion and metastasis, vascular angiogenesis and cancer drug resistance. In addition, we highlight the application of EVs in HNCs, underlining the special pathological and physiological environment of HNCs. The application of tumor heterogeneous EVs in saliva and circulating blood diagnostics will provide a new perspective for the early screening, real-time monitoring and prognostic risk assessment of HNCs. Given the concept of precise and individual therapy, nanostructured EVs are equipped with superior characteristics of biocompatibility, low immunogenicity, loadability and modification ability, making these molecules one of the new strategies for HNCs treatment. |
format | Online Article Text |
id | pubmed-6451295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64512952019-04-17 The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers Xie, Changqing Ji, Ning Tang, Zhangui Li, Jing Chen, Qianming Mol Cancer Review The proliferation and metastasis ability of tumors are mediate by the "mutual dialogue" between cells in the tumor microenvironment (TME). Extracellular vesicles (EVs), mainly exosomes and microvesicles, play an important role in achieving intercellular substance transport and information transfer in the TME. Initially considered "garbage dumpsters" and later referred to as "signal boxes", EVs carry "cargo" (proteins, lipids, or nucleic acids) that can redirect the function of a recipient cell. Currently, the molecular mechanisms and clinical applications of EVs in head and neck cancers (HNCs) are still at an early stage and need to be further investigate. In this review, we provide insight into the TME of HNCs, classifying and summarizing EVs derived from different cell types and illuminating their complex signaling networks involved in mediating tumor proliferation, invasion and metastasis, vascular angiogenesis and cancer drug resistance. In addition, we highlight the application of EVs in HNCs, underlining the special pathological and physiological environment of HNCs. The application of tumor heterogeneous EVs in saliva and circulating blood diagnostics will provide a new perspective for the early screening, real-time monitoring and prognostic risk assessment of HNCs. Given the concept of precise and individual therapy, nanostructured EVs are equipped with superior characteristics of biocompatibility, low immunogenicity, loadability and modification ability, making these molecules one of the new strategies for HNCs treatment. BioMed Central 2019-04-06 /pmc/articles/PMC6451295/ /pubmed/30954079 http://dx.doi.org/10.1186/s12943-019-0985-3 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Xie, Changqing Ji, Ning Tang, Zhangui Li, Jing Chen, Qianming The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
title | The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
title_full | The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
title_fullStr | The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
title_full_unstemmed | The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
title_short | The role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
title_sort | role of extracellular vesicles from different origin in the microenvironment of head and neck cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451295/ https://www.ncbi.nlm.nih.gov/pubmed/30954079 http://dx.doi.org/10.1186/s12943-019-0985-3 |
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