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PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications

We develop a simple, fast and economical surface treatment under ambient temperature to improve the hydrophilicity and osteoconductivity of polyetheretherketone (PEEK) for bone implant applications. A major challenge in bone implants is the drastic difference in stiffness between traditional implant...

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Detalles Bibliográficos
Autores principales: Wang, Weigeng, Luo, C. J., Huang, Jie, Edirisinghe, Mohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451405/
https://www.ncbi.nlm.nih.gov/pubmed/30836898
http://dx.doi.org/10.1098/rsif.2018.0955
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author Wang, Weigeng
Luo, C. J.
Huang, Jie
Edirisinghe, Mohan
author_facet Wang, Weigeng
Luo, C. J.
Huang, Jie
Edirisinghe, Mohan
author_sort Wang, Weigeng
collection PubMed
description We develop a simple, fast and economical surface treatment under ambient temperature to improve the hydrophilicity and osteoconductivity of polyetheretherketone (PEEK) for bone implant applications. A major challenge in bone implants is the drastic difference in stiffness between traditional implant materials (such as titanium and stainless steel) and human bone. PEEK is biocompatible with an elastic modulus closely matching that of human bone, making it a highly attractive alternative. However, its bio-inert and poorly hydrophilic surface presents a serious challenge for osseointegration. Sulfonation can improve hydrophilicity and introduce bioactive sulfonate groups, but PEEK sulfonation has traditionally been applied for fuel cells, employing elevated temperatures and long reaction times to re-cast PEEK into sulfonated films. Little research has systematically studied PEEK surface modification by short reaction time (seconds) and ambient-temperature sulfonation for biomedical applications. Here, we investigate three ambient-temperature sulfonation treatments under varying reaction times (5–90 s) and evaluate the hydrophilicity and morphology of 15 modified PEEK surfaces. We establish an optimal treatment using 30 s H(2)SO(4) followed by 20 s rinsing, and then 20 s immersion in NaOH followed by 20 s rinsing. This 30 s ambient-temperature sulfonation is found to be more effective than conventional plasma treatments and reduced PEEK water contact angle from 78° to 37°.
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spelling pubmed-64514052019-04-10 PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications Wang, Weigeng Luo, C. J. Huang, Jie Edirisinghe, Mohan J R Soc Interface Life Sciences–Engineering interface We develop a simple, fast and economical surface treatment under ambient temperature to improve the hydrophilicity and osteoconductivity of polyetheretherketone (PEEK) for bone implant applications. A major challenge in bone implants is the drastic difference in stiffness between traditional implant materials (such as titanium and stainless steel) and human bone. PEEK is biocompatible with an elastic modulus closely matching that of human bone, making it a highly attractive alternative. However, its bio-inert and poorly hydrophilic surface presents a serious challenge for osseointegration. Sulfonation can improve hydrophilicity and introduce bioactive sulfonate groups, but PEEK sulfonation has traditionally been applied for fuel cells, employing elevated temperatures and long reaction times to re-cast PEEK into sulfonated films. Little research has systematically studied PEEK surface modification by short reaction time (seconds) and ambient-temperature sulfonation for biomedical applications. Here, we investigate three ambient-temperature sulfonation treatments under varying reaction times (5–90 s) and evaluate the hydrophilicity and morphology of 15 modified PEEK surfaces. We establish an optimal treatment using 30 s H(2)SO(4) followed by 20 s rinsing, and then 20 s immersion in NaOH followed by 20 s rinsing. This 30 s ambient-temperature sulfonation is found to be more effective than conventional plasma treatments and reduced PEEK water contact angle from 78° to 37°. The Royal Society 2019-03 2019-03-06 /pmc/articles/PMC6451405/ /pubmed/30836898 http://dx.doi.org/10.1098/rsif.2018.0955 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Engineering interface
Wang, Weigeng
Luo, C. J.
Huang, Jie
Edirisinghe, Mohan
PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications
title PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications
title_full PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications
title_fullStr PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications
title_full_unstemmed PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications
title_short PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications
title_sort peek surface modification by fast ambient-temperature sulfonation for bone implant applications
topic Life Sciences–Engineering interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451405/
https://www.ncbi.nlm.nih.gov/pubmed/30836898
http://dx.doi.org/10.1098/rsif.2018.0955
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