Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive pathologies such as Crohn's disease or infect...

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Detalles Bibliográficos
Autores principales: Jones, Emily J., Matthews, Zoe J., Gul, Lejla, Sudhakar, Padhmanand, Treveil, Agatha, Divekar, Devina, Buck, Jasmine, Wrzesinski, Tomasz, Jefferson, Matthew, Armstrong, Stuart D., Hall, Lindsay J., Watson, Alastair J. M., Carding, Simon R., Haerty, Wilfried, Di Palma, Federica, Mayer, Ulrike, Powell, Penny P., Hautefort, Isabelle, Wileman, Tom, Korcsmaros, Tamas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451430/
https://www.ncbi.nlm.nih.gov/pubmed/30814064
http://dx.doi.org/10.1242/dmm.037069

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