Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy, however the mechanisms underlying therapeutic benefit of myeloid-targeting agents in combination with chemotherapy are incompletely understood. Here, we show that targeting tumor-associated macroph...

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Detalles Bibliográficos
Autores principales: Salvagno, Camilla, Ciampricotti, Metamia, Tuit, Sander, Hau, Cheei-Sing, van Weverwijk, Antoinette, Coffelt, Seth B., Kersten, Kelly, Vrijland, Kim, Kos, Kevin, Ulas, Thomas, Song, Ji-Ying, Ooi, Chia-Huey, Rüttinger, Dominik, Cassier, Philippe A., Jonkers, Jos, Schultze, Joachim L., Ries, Carola H., de Visser, Karin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451630/
https://www.ncbi.nlm.nih.gov/pubmed/30886344
http://dx.doi.org/10.1038/s41556-019-0298-1

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