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IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity

OBJECTIVE: A causal obesity risk variant in the FTO locus was recently shown to inhibit adipocyte thermogenesis via increased adipose expression of the homeobox transcription factors IRX3 and IRX5. However, causal effects of IRX5 on fat storage remain to be shown in vivo, and discovery of downstream...

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Detalles Bibliográficos
Autores principales:	Bjune, Jan-Inge, Haugen, Christine, Gudbrandsen, Oddrun, Nordbø, Ole P., Nielsen, Hans J., Våge, Villy, Njølstad, Pål R., Sagen, Jørn V., Dankel, Simon N., Mellgren, Gunnar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451637/ https://www.ncbi.nlm.nih.gov/pubmed/30538277 http://dx.doi.org/10.1038/s41366-018-0275-y

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