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Data from in vivo functionalization of diatom mesoporous biosilica with bisphosphonates

Diatoms are unicellular photosynthetic microalgae that produce a sophisticated mesoporous biosilica shell called frustule. Easy to achieve and extract, diatom frustules represent a low-cost source of mesoporous biocompatible biosilica. In this paper, the possibility to in vivo functionalize the diat...

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Detalles Bibliográficos
Autores principales: Leone, Gabriella, Vona, Danilo, De Giglio, Elvira, Bonifacio, Maria Addolorata, Cometa, Stefania, Fiore, Saverio, Palumbo, Fabio, Ragni, Roberta, Farinola, Gianluca M., Cicco, Stefania R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451687/
https://www.ncbi.nlm.nih.gov/pubmed/30997370
http://dx.doi.org/10.1016/j.dib.2019.103831
Descripción
Sumario:Diatoms are unicellular photosynthetic microalgae that produce a sophisticated mesoporous biosilica shell called frustule. Easy to achieve and extract, diatom frustules represent a low-cost source of mesoporous biocompatible biosilica. In this paper, the possibility to in vivo functionalize the diatom biosilica with bisphosphonates (BPs) was investigated. In particular, two BPs were tested: the amino-containing sodium alendronate (ALE) and the amino-lacking sodium etidronate (ETI). According to first SEM-EDX analysis, the presence of the amino-moiety in ALE structure allowed a better incorporation of this BP into living diatom biosilica, compared to ETI. Then, diatom growth was deeply investigated in presence of ALE. After extraction of functionalized frustules, ALE-biosilica was further characterized by XPS and microscopy, and ALE release was evaluated by ferrochelation assay. Moreover, the bone regeneration performances of ALE-functionalized frustules were preliminarily investigated on bone osteoblast-like cells, via Comassie staining. Data are related to the research article “In vivo functionalization of diatom biosilica with sodium alendronate as osteoactive material”.