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Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis

OBJECTIVES: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. METHODS: Here, we measured serum interleuk...

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Autores principales: Lin, Emily, Vincent, Fabien B, Sahhar, Joanne, Ngian, Gene‐Siew, Kandane‐Rathnayake, Rangi, Mende, Rachel, Morand, Eric F, Lang, Tali, Harris, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451750/
https://www.ncbi.nlm.nih.gov/pubmed/30997045
http://dx.doi.org/10.1002/cti2.1045
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author Lin, Emily
Vincent, Fabien B
Sahhar, Joanne
Ngian, Gene‐Siew
Kandane‐Rathnayake, Rangi
Mende, Rachel
Morand, Eric F
Lang, Tali
Harris, James
author_facet Lin, Emily
Vincent, Fabien B
Sahhar, Joanne
Ngian, Gene‐Siew
Kandane‐Rathnayake, Rangi
Mende, Rachel
Morand, Eric F
Lang, Tali
Harris, James
author_sort Lin, Emily
collection PubMed
description OBJECTIVES: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. METHODS: Here, we measured serum interleukin (IL)‐1α, IL‐1β and IL‐18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. RESULTS: Serum IL‐18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL‐1α and IL‐1β were observed between SSc and HC. In both SSc and HC serum, IL‐1α and IL‐1β were positively correlated, while in SSc, both cytokines negatively correlated with IL‐18. Serum IL‐18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL‐1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL‐1β. Serum IL‐1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL‐1α concentrations were more likely to have digital ulcers. CONCLUSIONS: Our data suggest that these IL‐1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications.
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spelling pubmed-64517502019-04-17 Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis Lin, Emily Vincent, Fabien B Sahhar, Joanne Ngian, Gene‐Siew Kandane‐Rathnayake, Rangi Mende, Rachel Morand, Eric F Lang, Tali Harris, James Clin Transl Immunology Original Articles OBJECTIVES: Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SSc remains poorly understood, although studies have indicated a role for the innate immune response. METHODS: Here, we measured serum interleukin (IL)‐1α, IL‐1β and IL‐18 levels in 105 SSc patients and 47 healthy controls (HC) and analysed them with respect to multiple clinical parameters. RESULTS: Serum IL‐18 concentrations were significantly higher in SSc patients than in HC, while no significant differences in concentrations of IL‐1α and IL‐1β were observed between SSc and HC. In both SSc and HC serum, IL‐1α and IL‐1β were positively correlated, while in SSc, both cytokines negatively correlated with IL‐18. Serum IL‐18 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO) and diffusing capacity of the lungs for carbon monoxide (DLCO). Serum IL‐1β was positively correlated with the modified Rodnan skin score (mRSS), particularly in patients with limited subtype. DLCO, KCO and tricuspid regurgitation (TR) velocity were significantly higher in patients with high serum IL‐1β. Serum IL‐1α was significantly lower in SSc patients with low KCO and positively correlated with KCO. SSc patients with high serum IL‐1α concentrations were more likely to have digital ulcers. CONCLUSIONS: Our data suggest that these IL‐1 family cytokines may have different roles in the pathogenesis of SSc fibrotic complications. John Wiley and Sons Inc. 2019-04-06 /pmc/articles/PMC6451750/ /pubmed/30997045 http://dx.doi.org/10.1002/cti2.1045 Text en © 2019 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Lin, Emily
Vincent, Fabien B
Sahhar, Joanne
Ngian, Gene‐Siew
Kandane‐Rathnayake, Rangi
Mende, Rachel
Morand, Eric F
Lang, Tali
Harris, James
Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
title Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
title_full Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
title_fullStr Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
title_full_unstemmed Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
title_short Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients with systemic sclerosis
title_sort analysis of serum interleukin(il)‐1α, il‐1β and il‐18 in patients with systemic sclerosis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451750/
https://www.ncbi.nlm.nih.gov/pubmed/30997045
http://dx.doi.org/10.1002/cti2.1045
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