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Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field

Effects of pulsed electromagnetic field (PEMF) on hematology and hematopoiesis might vary with different PEMF parameters. The purpose of this study was to evaluate the possible effects of PEMF exposure at different pulses on hematologic and hematopoietic parameters in mice. Groups of male BALB/c mic...

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Autores principales: Li, Kangchu, Teng, Zenghui, Liu, Zhaohui, Zhang, Yuxing, Long, Kaiping, Liao, Qimei, Ni, Ansheng, Ding, Guirong, Ma, Shirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451797/
https://www.ncbi.nlm.nih.gov/pubmed/31019981
http://dx.doi.org/10.1155/2019/3628956
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author Li, Kangchu
Teng, Zenghui
Liu, Zhaohui
Zhang, Yuxing
Long, Kaiping
Liao, Qimei
Ni, Ansheng
Ding, Guirong
Ma, Shirong
author_facet Li, Kangchu
Teng, Zenghui
Liu, Zhaohui
Zhang, Yuxing
Long, Kaiping
Liao, Qimei
Ni, Ansheng
Ding, Guirong
Ma, Shirong
author_sort Li, Kangchu
collection PubMed
description Effects of pulsed electromagnetic field (PEMF) on hematology and hematopoiesis might vary with different PEMF parameters. The purpose of this study was to evaluate the possible effects of PEMF exposure at different pulses on hematologic and hematopoietic parameters in mice. Groups of male BALB/c mice were whole body exposed or were sham exposed (control) to PEMF at 100, 1000, and 10000 pulses. After PEMF exposure, blood samples and bone marrow cells of mice were collected for hematologic examinations, bone marrow nucleated cell counting, colony-forming units of granulocyte-macrophage (CFU-GM) colony assay, and serum granulocyte-macrophage colony-stimulating factor (GM-CSF) assay. Compared with the control group, white blood cells (WBC) and lymphocytes (LYM) in the 100 and 1000 pulses exposed groups were significantly increased but not changed in the 10000 pulses exposed group. Red blood cells (RBC), hemoglobin (HGB), and platelets (PLT) were not changed in all exposed groups. There was no significant difference in mouse bone marrow nucleated cell number between the control group and each exposed group 7 days after PEMF exposure. The CFU-GM clone number of bone marrow cells and serum GM-CSF level were significantly increased in the 100 and 1000 pulses exposed group but not changed in the 10000 pulses exposed group. Our results indicated that the PEMF exposure at fewer pulses may induce statistically significant alterations in some hematologic and hematopoietic parameters of mice but no changes can be found in the more pulses PEMF-exposed groups.
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spelling pubmed-64517972019-04-24 Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field Li, Kangchu Teng, Zenghui Liu, Zhaohui Zhang, Yuxing Long, Kaiping Liao, Qimei Ni, Ansheng Ding, Guirong Ma, Shirong J Immunol Res Research Article Effects of pulsed electromagnetic field (PEMF) on hematology and hematopoiesis might vary with different PEMF parameters. The purpose of this study was to evaluate the possible effects of PEMF exposure at different pulses on hematologic and hematopoietic parameters in mice. Groups of male BALB/c mice were whole body exposed or were sham exposed (control) to PEMF at 100, 1000, and 10000 pulses. After PEMF exposure, blood samples and bone marrow cells of mice were collected for hematologic examinations, bone marrow nucleated cell counting, colony-forming units of granulocyte-macrophage (CFU-GM) colony assay, and serum granulocyte-macrophage colony-stimulating factor (GM-CSF) assay. Compared with the control group, white blood cells (WBC) and lymphocytes (LYM) in the 100 and 1000 pulses exposed groups were significantly increased but not changed in the 10000 pulses exposed group. Red blood cells (RBC), hemoglobin (HGB), and platelets (PLT) were not changed in all exposed groups. There was no significant difference in mouse bone marrow nucleated cell number between the control group and each exposed group 7 days after PEMF exposure. The CFU-GM clone number of bone marrow cells and serum GM-CSF level were significantly increased in the 100 and 1000 pulses exposed group but not changed in the 10000 pulses exposed group. Our results indicated that the PEMF exposure at fewer pulses may induce statistically significant alterations in some hematologic and hematopoietic parameters of mice but no changes can be found in the more pulses PEMF-exposed groups. Hindawi 2019-03-24 /pmc/articles/PMC6451797/ /pubmed/31019981 http://dx.doi.org/10.1155/2019/3628956 Text en Copyright © 2019 Kangchu Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Kangchu
Teng, Zenghui
Liu, Zhaohui
Zhang, Yuxing
Long, Kaiping
Liao, Qimei
Ni, Ansheng
Ding, Guirong
Ma, Shirong
Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field
title Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field
title_full Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field
title_fullStr Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field
title_full_unstemmed Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field
title_short Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field
title_sort alterations of hematologic and hematopoietic parameters in mice exposed to pulsed electromagnetic field
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451797/
https://www.ncbi.nlm.nih.gov/pubmed/31019981
http://dx.doi.org/10.1155/2019/3628956
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