The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma

The mutations of TP53 gene are frequently observed in canine histiocytic sarcoma (HS). The objective of this study was to examine the distribution of tumor cells with TP53 gene mutations. Tumor tissues were divided into three or four regions and TP53 gene mutations were examined. TP53 gene mutations...

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Autores principales: ASADA, Hajime, ICHII, Osamu, TOMIYASU, Hirotaka, UCHIDA, Kazuyuki, CHAMBERS, James K., GOTO-KOSHINO, Yuko, OHNO, Koichi, KON, Yasuhiro, TSUJIMOTO, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451907/
https://www.ncbi.nlm.nih.gov/pubmed/30662044
http://dx.doi.org/10.1292/jvms.18-0419
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author ASADA, Hajime
ICHII, Osamu
TOMIYASU, Hirotaka
UCHIDA, Kazuyuki
CHAMBERS, James K.
GOTO-KOSHINO, Yuko
OHNO, Koichi
KON, Yasuhiro
TSUJIMOTO, Hajime
author_facet ASADA, Hajime
ICHII, Osamu
TOMIYASU, Hirotaka
UCHIDA, Kazuyuki
CHAMBERS, James K.
GOTO-KOSHINO, Yuko
OHNO, Koichi
KON, Yasuhiro
TSUJIMOTO, Hajime
author_sort ASADA, Hajime
collection PubMed
description The mutations of TP53 gene are frequently observed in canine histiocytic sarcoma (HS). The objective of this study was to examine the distribution of tumor cells with TP53 gene mutations. Tumor tissues were divided into three or four regions and TP53 gene mutations were examined. TP53 gene mutations were detected only in parts of the HS tissues from six of the eight dogs, and the frequency of the mutant allele varied (0–65%) among the tumor regions. This study suggests that canine HS can exhibit intratumor heterogeneity. Further studies are needed to examine the clinical significance of the intratumor heterogeneity of TP53 gene mutations.
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spelling pubmed-64519072019-04-10 The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma ASADA, Hajime ICHII, Osamu TOMIYASU, Hirotaka UCHIDA, Kazuyuki CHAMBERS, James K. GOTO-KOSHINO, Yuko OHNO, Koichi KON, Yasuhiro TSUJIMOTO, Hajime J Vet Med Sci Internal Medicine The mutations of TP53 gene are frequently observed in canine histiocytic sarcoma (HS). The objective of this study was to examine the distribution of tumor cells with TP53 gene mutations. Tumor tissues were divided into three or four regions and TP53 gene mutations were examined. TP53 gene mutations were detected only in parts of the HS tissues from six of the eight dogs, and the frequency of the mutant allele varied (0–65%) among the tumor regions. This study suggests that canine HS can exhibit intratumor heterogeneity. Further studies are needed to examine the clinical significance of the intratumor heterogeneity of TP53 gene mutations. The Japanese Society of Veterinary Science 2019-01-18 2019-03 /pmc/articles/PMC6451907/ /pubmed/30662044 http://dx.doi.org/10.1292/jvms.18-0419 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
ASADA, Hajime
ICHII, Osamu
TOMIYASU, Hirotaka
UCHIDA, Kazuyuki
CHAMBERS, James K.
GOTO-KOSHINO, Yuko
OHNO, Koichi
KON, Yasuhiro
TSUJIMOTO, Hajime
The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma
title The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma
title_full The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma
title_fullStr The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma
title_full_unstemmed The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma
title_short The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma
title_sort intratumor heterogeneity of tp53 gene mutations in canine histiocytic sarcoma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451907/
https://www.ncbi.nlm.nih.gov/pubmed/30662044
http://dx.doi.org/10.1292/jvms.18-0419
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