Cargando…

Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer

BACKGROUND: Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract. The worldwide mortality rate of CRC is about one half of its morbidity. Ubiquitin is a key regulatory factor in the cell cycle and widely exists in eukaryotes. Human leukocyte antigen F-associated transcript 10...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Chun-Yang, Sun, Jie, Wang, Xing, Wang, Cui-Fang, Zeng, Xian-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451929/
https://www.ncbi.nlm.nih.gov/pubmed/30984346
http://dx.doi.org/10.4251/wjgo.v11.i1.9
_version_ 1783409239093411840
author Zhang, Chun-Yang
Sun, Jie
Wang, Xing
Wang, Cui-Fang
Zeng, Xian-Dong
author_facet Zhang, Chun-Yang
Sun, Jie
Wang, Xing
Wang, Cui-Fang
Zeng, Xian-Dong
author_sort Zhang, Chun-Yang
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract. The worldwide mortality rate of CRC is about one half of its morbidity. Ubiquitin is a key regulatory factor in the cell cycle and widely exists in eukaryotes. Human leukocyte antigen F-associated transcript 10 (FAT10), known as diubiquitin, is an 18 kDa protein with 29% and 36% homology with the N and C termini of ubiquitin. The function of FAT10 has not been fully elucidated, and some studies have shown that it plays an important role in various cell processes. AIM: To examine FAT10 expression and to analyze the relationship between FAT10 expression and the clinicopathological parameters of CRC. METHODS: FAT10 expression in 61 cases of CRC and para-cancer colorectal tissues was measured by immunohistochemistry and Western blotting. The relationship between FAT10 expression and clinicopathological parameters of CRC was statistically analyzed. RESULTS: Immunohistochemical analysis showed that the positive rate of FAT10 expression in CRC (63.93%) was significantly higher than that in tumor-adjacent tissues (9.84%, P < 0.05) and normal colorectal mucosal tissue (1.64%, P < 0.05). Western blotting also indicated that FAT10 expression was significantly higher in CRC than in tumor-adjacent tissue (P < 0.05). FAT10 expression was closely associated with clinical stage and lymphatic spread of CRC. FAT10 expression also positively correlated with p53 expression. CONCLUSION: FAT10 expression is highly upregulated in CRC. FAT10 expression is closely associated with clinical stage and lymphatic spread of CRC.
format Online
Article
Text
id pubmed-6451929
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-64519292019-04-12 Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer Zhang, Chun-Yang Sun, Jie Wang, Xing Wang, Cui-Fang Zeng, Xian-Dong World J Gastrointest Oncol Basic Study BACKGROUND: Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract. The worldwide mortality rate of CRC is about one half of its morbidity. Ubiquitin is a key regulatory factor in the cell cycle and widely exists in eukaryotes. Human leukocyte antigen F-associated transcript 10 (FAT10), known as diubiquitin, is an 18 kDa protein with 29% and 36% homology with the N and C termini of ubiquitin. The function of FAT10 has not been fully elucidated, and some studies have shown that it plays an important role in various cell processes. AIM: To examine FAT10 expression and to analyze the relationship between FAT10 expression and the clinicopathological parameters of CRC. METHODS: FAT10 expression in 61 cases of CRC and para-cancer colorectal tissues was measured by immunohistochemistry and Western blotting. The relationship between FAT10 expression and clinicopathological parameters of CRC was statistically analyzed. RESULTS: Immunohistochemical analysis showed that the positive rate of FAT10 expression in CRC (63.93%) was significantly higher than that in tumor-adjacent tissues (9.84%, P < 0.05) and normal colorectal mucosal tissue (1.64%, P < 0.05). Western blotting also indicated that FAT10 expression was significantly higher in CRC than in tumor-adjacent tissue (P < 0.05). FAT10 expression was closely associated with clinical stage and lymphatic spread of CRC. FAT10 expression also positively correlated with p53 expression. CONCLUSION: FAT10 expression is highly upregulated in CRC. FAT10 expression is closely associated with clinical stage and lymphatic spread of CRC. Baishideng Publishing Group Inc 2019-01-15 2019-01-15 /pmc/articles/PMC6451929/ /pubmed/30984346 http://dx.doi.org/10.4251/wjgo.v11.i1.9 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Basic Study
Zhang, Chun-Yang
Sun, Jie
Wang, Xing
Wang, Cui-Fang
Zeng, Xian-Dong
Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
title Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
title_full Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
title_fullStr Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
title_full_unstemmed Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
title_short Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
title_sort clinicopathological significance of human leukocyte antigen f-associated transcript 10 expression in colorectal cancer
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451929/
https://www.ncbi.nlm.nih.gov/pubmed/30984346
http://dx.doi.org/10.4251/wjgo.v11.i1.9
work_keys_str_mv AT zhangchunyang clinicopathologicalsignificanceofhumanleukocyteantigenfassociatedtranscript10expressionincolorectalcancer
AT sunjie clinicopathologicalsignificanceofhumanleukocyteantigenfassociatedtranscript10expressionincolorectalcancer
AT wangxing clinicopathologicalsignificanceofhumanleukocyteantigenfassociatedtranscript10expressionincolorectalcancer
AT wangcuifang clinicopathologicalsignificanceofhumanleukocyteantigenfassociatedtranscript10expressionincolorectalcancer
AT zengxiandong clinicopathologicalsignificanceofhumanleukocyteantigenfassociatedtranscript10expressionincolorectalcancer