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Dynamic transcriptomic analysis reveals suppression of PGC1α/ERRα drives perturbed myogenesis in facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked to epigenetic derepression of D4Z4 repeats on chromosome 4q, leading to ectopic DUX4 expression. FSHD patient myoblasts have defective myogenic differentiation, forming smaller myotubes with reduced myosin conte...

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Detalles Bibliográficos
Autores principales:	Banerji, Christopher R S, Panamarova, Maryna, Pruller, Johanna, Figeac, Nicolas, Hebaishi, Husam, Fidanis, Efthymios, Saxena, Alka, Contet, Julian, Sacconi, Sabrina, Severini, Simone, Zammit, Peter S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452176/ https://www.ncbi.nlm.nih.gov/pubmed/30462217 http://dx.doi.org/10.1093/hmg/ddy405

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