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Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic

The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate...

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Autores principales: Morens, David M, Taubenberger, Jeffery K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452324/
https://www.ncbi.nlm.nih.gov/pubmed/30715352
http://dx.doi.org/10.1093/infdis/jiy728
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author Morens, David M
Taubenberger, Jeffery K
author_facet Morens, David M
Taubenberger, Jeffery K
author_sort Morens, David M
collection PubMed
description The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths.
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spelling pubmed-64523242020-04-08 Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic Morens, David M Taubenberger, Jeffery K J Infect Dis Supplement Articles The year 2018 marked the 100th anniversary of the deadliest event in human history. In 1918–1919, pandemic influenza spread globally and caused an estimated 50–100 million deaths associated with unexpected clinical and epidemiological features. The descendants of the 1918 virus continue to circulate as annual epidemic viruses causing significant mortality each year. The 1918 influenza pandemic serves as a benchmark for the development of universal influenza vaccines. Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia. Perhaps the most important goal of such vaccines is not to prevent influenza, but to prevent influenza deaths. Oxford University Press 2019-04-15 2019-04-08 /pmc/articles/PMC6452324/ /pubmed/30715352 http://dx.doi.org/10.1093/infdis/jiy728 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Supplement Articles
Morens, David M
Taubenberger, Jeffery K
Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
title Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
title_full Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
title_fullStr Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
title_full_unstemmed Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
title_short Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic
title_sort making universal influenza vaccines: lessons from the 1918 pandemic
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452324/
https://www.ncbi.nlm.nih.gov/pubmed/30715352
http://dx.doi.org/10.1093/infdis/jiy728
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