Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG...

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Autores principales: Montejo, Carmen, Navarro‐Otano, Judith, Mayà‐Casalprim, Gerard, Campolo, Michela, Casanova‐Mollá, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452470/
https://www.ncbi.nlm.nih.gov/pubmed/30997053
http://dx.doi.org/10.1002/ccr3.2026
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author Montejo, Carmen
Navarro‐Otano, Judith
Mayà‐Casalprim, Gerard
Campolo, Michela
Casanova‐Mollá, Jordi
author_facet Montejo, Carmen
Navarro‐Otano, Judith
Mayà‐Casalprim, Gerard
Campolo, Michela
Casanova‐Mollá, Jordi
author_sort Montejo, Carmen
collection PubMed
description Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity.
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spelling pubmed-64524702019-04-17 Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review Montejo, Carmen Navarro‐Otano, Judith Mayà‐Casalprim, Gerard Campolo, Michela Casanova‐Mollá, Jordi Clin Case Rep Case Reports Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity. John Wiley and Sons Inc. 2019-02-19 /pmc/articles/PMC6452470/ /pubmed/30997053 http://dx.doi.org/10.1002/ccr3.2026 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Montejo, Carmen
Navarro‐Otano, Judith
Mayà‐Casalprim, Gerard
Campolo, Michela
Casanova‐Mollá, Jordi
Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
title Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
title_full Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
title_fullStr Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
title_full_unstemmed Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
title_short Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review
title_sort acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: case report and literature review
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452470/
https://www.ncbi.nlm.nih.gov/pubmed/30997053
http://dx.doi.org/10.1002/ccr3.2026
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