Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles

We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation. Despite multiple drug‐drug interactions, maintaining therapeutic TCS levels was...

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Detalles Bibliográficos
Autores principales: Chouchane, Ikrame, Stremler‐Lebel, Nathalie, Reix, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452481/
https://www.ncbi.nlm.nih.gov/pubmed/30997048
http://dx.doi.org/10.1002/ccr3.2053
Descripción
Sumario:We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation. Despite multiple drug‐drug interactions, maintaining therapeutic TCS levels was achievable. During the following year, LUM/IVA was well tolerated, providing clinical benefits.

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