Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles

We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation. Despite multiple drug‐drug interactions, maintaining therapeutic TCS levels was...

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Detalles Bibliográficos
Autores principales: Chouchane, Ikrame, Stremler‐Lebel, Nathalie, Reix, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452481/
https://www.ncbi.nlm.nih.gov/pubmed/30997048
http://dx.doi.org/10.1002/ccr3.2053
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author Chouchane, Ikrame
Stremler‐Lebel, Nathalie
Reix, Philippe
author_facet Chouchane, Ikrame
Stremler‐Lebel, Nathalie
Reix, Philippe
author_sort Chouchane, Ikrame
collection PubMed
description We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation. Despite multiple drug‐drug interactions, maintaining therapeutic TCS levels was achievable. During the following year, LUM/IVA was well tolerated, providing clinical benefits.
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spelling pubmed-64524812019-04-17 Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles Chouchane, Ikrame Stremler‐Lebel, Nathalie Reix, Philippe Clin Case Rep Case Reports We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation. Despite multiple drug‐drug interactions, maintaining therapeutic TCS levels was achievable. During the following year, LUM/IVA was well tolerated, providing clinical benefits. John Wiley and Sons Inc. 2019-02-17 /pmc/articles/PMC6452481/ /pubmed/30997048 http://dx.doi.org/10.1002/ccr3.2053 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Chouchane, Ikrame
Stremler‐Lebel, Nathalie
Reix, Philippe
Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
title Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
title_full Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
title_fullStr Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
title_full_unstemmed Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
title_short Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
title_sort lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452481/
https://www.ncbi.nlm.nih.gov/pubmed/30997048
http://dx.doi.org/10.1002/ccr3.2053
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AT reixphilippe lumacaftorivacaftorinitiationintwolivertransplantationpatientsundertacrolimusandantifungalazoles

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