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Defining a new nomenclature for the structures of active and inactive kinases
Targeting protein kinases is an important strategy for intervention in cancer. Inhibitors are directed at the active conformation or a variety of inactive conformations. While attempts have been made to classify these conformations, a structurally rigorous catalog of states has not been achieved. Th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452665/ https://www.ncbi.nlm.nih.gov/pubmed/30867294 http://dx.doi.org/10.1073/pnas.1814279116 |