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Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

The long-chain fatty acid receptor FFAR1/GPR40 binds agonists in both an interhelical site between the extracellular segments of transmembrane helix (TM)-III and TM-IV and a lipid-exposed groove between the intracellular segments of these helices. Molecular dynamics simulations of FFAR1 with agonist...

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Detalles Bibliográficos
Autores principales:	Lückmann, Michael, Trauelsen, Mette, Bentsen, Marie A., Nissen, Tinne A. D., Martins, Joao, Fallah, Zohreh, Nygaard, Mads M., Papaleo, Elena, Lindorff-Larsen, Kresten, Schwartz, Thue W., Frimurer, Thomas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452680/ https://www.ncbi.nlm.nih.gov/pubmed/30872479 http://dx.doi.org/10.1073/pnas.1811066116

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