p27 transcriptionally coregulates cJun to drive programs of tumor progression

p27 shifts from CDK inhibitor to oncogene when phosphorylated by PI3K effector kinases. Here, we show that p27 is a cJun coregulator, whose assembly and chromatin association is governed by p27 phosphorylation. In breast and bladder cancer cells with high p27pT157pT198 or expressing a CDK-binding de...

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Detalles Bibliográficos
Autores principales: Yoon, Hyunho, Kim, Minsoon, Jang, Kibeom, Shin, Miyoung, Besser, Alexandra, Xiao, Xue, Zhao, Dekuang, Wander, Seth A., Briegel, Karoline, Morey, Lluis, Minn, Andy, Slingerland, Joyce M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452716/
https://www.ncbi.nlm.nih.gov/pubmed/30877256
http://dx.doi.org/10.1073/pnas.1817415116

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